Gabapentin Abuse and Overdose: A Case Report
نویسندگان
چکیده
The abuse potential of drugs that stimulate dopamine release has driven the search for drugs that influence alternate neurotransmitters, and the glutaminergic pathway is a potential target for the development of new therapeutic practices [1]. Gabapentin is one such drug that modulates GABA and glutamate levels; its clinical effectiveness has been reported across a wide variety of disorders ranging from neuropathic pain and epilepsy to psychiatric disorders. While abuse potential for gabapentin is less than that for dopamine agonists, relatively large amounts of the drug can induce the “high” that abusers seek. Little research and attention has been generated with regards to gabapentin abuse potential. Also, the role of acetlycysteine in treating gabapentin overdose has received virtually no attention, and yet, this is the recommended treatment by poison control. It is for these reasons that we present a case of gabapentin abuse and overdose.
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